Apixaban compared with warfarin for stroke prevention in atrial fibrillation: implications of time in therapeutic range.
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منابع مشابه
Rivaroxaban in atrial fibrillation
Warfarin is the traditional therapeutic option available to manage thromboembolic risk in atrial fibrillation. The hemorrhagic risk with warfarin depends mainly on the international normalized ratio (INR). Data from randomized controlled trials show that patients have a therapeutic INR (2.00-3.00) only 61%-68% of the time while taking warfarin, and this target is sometimes hard to establish. Ma...
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*Attending Cardiologist, **Consultant Cardiologist, Fortis Escorts Heart Institute, Okhla, New Delhi Received: 20.09.2012; Accepted: 08.11.2012 Sir, D thrombin inhibitors potentially have advantages over vitamin K antagonists (VKAs) like early onset of action, less drug interactions and therapeutic effect which is predictable. This may relieve the physician and patient stress of regular prothro...
متن کاملNewer Oral Anticoagulants: Stroke Prevention and Pitfalls
Warfarin is very effective in preventing stroke in patients with atrial fibrillation. However, its use is limited due to fear of hemorrhagic complications, unpredictable anticoagulant effects related to multiple drug interactions and dietary restrictions, a narrow therapeutic window, frequent difficulty maintaining the anticoagulant effect within a narrow therapeutic window, and the need for in...
متن کاملCost-effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for stroke prevention in atrial fibrillation.
BACKGROUND AND PURPOSE To estimate the cost-effectiveness of stroke prevention in patients with nonvalvular atrial fibrillation by using novel oral anticoagulants apixaban 5 mg, dabigatran 150 mg, and rivaroxaban 20 mg compared with warfarin. METHODS A Markov decision-analysis model was constructed using data from clinical trials to evaluate lifetime costs and quality-adjusted life-years of n...
متن کاملBleeding During Treatment With Aspirin Versus Apixaban in Patients With Atrial Fibrillation Unsuitable for Warfarin The Apixaban Versus Acetylsalicylic Acid to Prevent Stroke in Atrial Fibrillation Patients Who Have Failed or Are Unsuitable for Vitamin
T he efficacy of warfarin for stroke prevention in patients with atrial fibrillation (AF) is well established by randomized clinical trials but vitamin k antagonists (VKAs) remain underused in clinical practice. Many patients who do not receive VKA receive aspirin for stroke prevention. Apixaban, a novel oral Factor Xa inhibitor, is superior to aspirin for prevention of stroke in patients with ...
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عنوان ژورنال:
- Circulation
دوره 127 22 شماره
صفحات -
تاریخ انتشار 2013